prevalence of drug resistance in nonfermenter gram-negative bacilli
Authors
abstract
background and objectives: non-fementer gram-negative bacilli (nfgb) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. the aim of this study was to determine the prevalence and antimicrobial susceptibility of nfgb in an iranian hospital. materials and methods: fromjuly 2005 to november 2006 a total of 257 strains of nfgb including 109 (42.41%) strains of pseudomonas aeruoginosa, 88 (34.24%) strains of acinetobacter baumannii, 48 (18.67%) stains of stenotrophomonas maltophilia and 12 (4.66%) strains of burkholderia cepacia were isolated from clinical specimens taken from patients hospitalized in an iranian 1000–bed tertiary care hospital[d1] . conventional bacteriological methods were used for identification and susceptibility testing of nfgb. susceptibility testing was performed by method as recommended by clinical laboratory standard institute (clsi). data were analyzed using spss 11.5 for windows (spss inc., chicago, il) results: a total of 257 non-duplicating of nfgb strains were isolated from 234 hospitalized patients. the most effective antibiotic against p. aeruginosa and a. baumannii was imipenem followed by tobramycin. fluoroquinolones had moderate activity against p. aerugunosa. most isolates of a.baumannii were multi-drug resistant. susceptibility of s. maltophila to ticarcillin- clavuanic, ofloxacin and ceftazidim was 96%, 94% and 81%, respectively. thirty three percent of this bacterium isolates were resistant to co-trimoxazole. conclusion: in our study, imipenem was the most effective antibiotic against p. aeruginosa and a. baummannii isolates. previous history use of antibiotics, longer duration of hospital stay and mechanical ventilation were the major risk factors for resistance acquisition in nfgb especially in p. aeruginosa and a. baumannii.
similar resources
Prevalence of Drug Resistance in Nonfermenter Gram-Negative Bacilli
Background and Objectives: Non-fementer gram-negative bacilli (NFGB) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. The aim of this study was to determine the prevalence and antimicrobial susceptibility of NFGB in an Iranian hospital. Materials and Methods: FromJuly 2005 to November 2006 a total of 257 strains of NFGB including 109 (42.41%)...
full textGRAM NEGATIVE BACILLI IN BURNS
In a period of nine months, 225 strains of Gram-negative bacilli isolated from burns were identified by a variety of tests in two burn centers in Tehran. The most common species were Pseudomonas aeruginosa, Pseudomonas fluorescens, Escherichia coli, Enterobacter agglomerans, Enterobacter cloacae and Klebsiella pneumoniae. Many strains of acinetobacter spp, providencia spp, proteus spp, ser...
full textAminoglycoside Resistance in Gram-negative Bacilli
Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of an enzyme that modifies aminoglycosides, 2. Impaired entry of aminoglycoside into the cell by altering the OMP permeability, decreasing inner membrane transport, or active efflux, ...
full textPrevalence of Gram Negative Bacilli Isolated from the Equipment and Surfaces of Hospitals in Gorgan
Abstract Background and Objective: Nosocomial infection is one of the main factors of mortality in hospitals . One of the most important measures to control infection in hospitals is sampling of equipment and culturing the samples . This study aimed to investigate the prevalence of gram-negative bacilli obtained from the equipment of the hospital wards . Material...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of pathologyPublisher: iranian society of pathology
ISSN 1735-5303
volume 5
issue 2 2010
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023